BOLALARDA O'TKIR PYELONEFRITNI DIAGNOSTIKASIDA INNOVATSION JIHATLAR
Abstract
Piyelonefrit - bolalarda o'tkir respiratorli infektsiyalardan keyin ikkinchi o'rinda turadi va ular o'rtasida aniq va yaqin aloqalar mavjud. Maqsad. COVID-19 bilan kasallangan bolalarda piyelonefritni erta tashxislashning klinik va laboratoriya xususiyatlarini baholash. Usullari. Piyelonefrit bilan og'rigan 121 bolani kuzatuvchi kohort retrospektiv klinik tadqiqoti o'tkazildi. Natijalar va muhokama. Piyelonefrit bilan og'rigan barcha bemorlarda qisman buyrak funktsiyasidagi o'zgarishlarni tahlil qildik. Tadqiqot natijalari shuni ko'rsatadiki, 1 va 3-guruhdagi bemorlarda barcha o'rganilgan klinik va laboratoriya ko'rsatkichlari 2-guruhga nisbatan sezilarli darajada buzilgan. Bu o'zgarishlar kasallikning sabablari (etiologik omillar) ga qarab o'zlarini boshqacha ko'rsatishi mumkinligini tasdiqlaydi. Xulosa. COVID-19 bilan kasallangan piyelonefritli bemorlarda buyrak nefronlarining nafaqat proksimal (proteinuriya sog'lom bolalarga nisbatan 11 baravar ko'paydi) va distal kanalchalari (ammoniogenez funktsiyasi 34% ga kamaydi), balki glomerulalarning shikastlanishi ham aniqlandi (sog'lom bolalarda anamnezda piyelonefrit bilan solishtirganda KFT 38% ga kamaygan).
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