CLINICAL, RADIOGRAPHIC, AND MOLECULAR METHODS FOR EARLY DIAGNOSIS OF PERI-IMPLANTITIS

Authors

  • Adilov K.Z., Adilova Sh.T. Tashkent State Medical University, Alfarganus University

Abstract

Peri-implantitis is a chronic inflammatory disease of peri-implant tissues, characterized by progressive marginal bone loss and the risk of implant failure. Early and accurate diagnosis is essential to ensure timely intervention and improve treatment outcomes. Conventional clinical methods, including probing depth, bleeding on probing, and suppuration, as well as radiographic assessment of bone levels, remain the cornerstone of diagnosis [1,3]. However, recent advances in the analysis of peri-implant crevicular fluid (PICF) biomarkers and molecular technologies enable the detection of pathological processes before clinical manifestations become evident [2,5,6]. Integration of clinical, radiographic, and molecular approaches enhances diagnostic accuracy and facilitates prediction of disease progression.

References

1. Delucchi F., Canepa C., Canullo L., Pesce P., Isola G., Menini M. Biomarkers from Peri Implant Crevicular Fluid (PICF) as Predictors of Peri Implant Bone Loss: A Systematic Review // International Journal of Molecular Sciences. – 2023. – Vol. 24, № 4:3202. – DOI:10.3390/ijms24043202

2. Kido R., Kido J., Nishikawa Y. et al. Diagnosis of inflammatory peri implant diseases using an immunochromatographic assay for calprotectin in peri implant crevicular fluid // International Journal of Implant Dentistry. – 2021. – 7:106. – DOI:10.1186/s40729-021-00386-z

3. La Monaca G., Pranno N., Patini R., Polimeni A., Cordaro M., Cristalli M.P. Biomarkers in Peri Implant Crevicular Fluid of Healthy Implants and Those With Peri Implant Diseases: A Systematic Review and Meta Analysis // Journal of Oral Pathology & Medicine. – 2025. – Vol. 54, № 5:267–282. – DOI:10.1111/jop.13612

4. Mid infrared spectroscopy analysis of peri implant crevicular fluid in peri implantitis: Pilot study // Clinical Oral Implants Research. – 2026. – Автор не указан. – DOI:10.1111/clr.70091

5. Pliavga V., Peceliunaite G., Daugela P., Leketas M., Gervickas A., Juodzbalys G. Peri implantitis Diagnosis and Prognosis Using Biomarkers: A Systematic Literature Review // International Journal of Oral & Maxillofacial Implants. – 2023. – Vol. 38, № 6:1095–1105. – DOI:10.11607/jomi.10353

6. Ramanathan A. A scoping review of diagnostic techniques used for early detection of peri implant diseases // Frontiers in Dental Medicine. – 2025. – Автор не указан

7. Role of pro-inflammatory cytokines in the pathophysiology of peri-implantitis: current data and future perspectives // International Research Journal. – 2025;8(158). – Автор не указан – DOI:10.60797/IRJ.2025.158.16

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Published

2026-02-03

How to Cite

Adilov K.Z., Adilova Sh.T. (2026). CLINICAL, RADIOGRAPHIC, AND MOLECULAR METHODS FOR EARLY DIAGNOSIS OF PERI-IMPLANTITIS. Modern World Education: New Age Problems – New Solutions, 3(2), 170–171. Retrieved from https://incop.org/index.php/mo/article/view/3482