BOLALARDA COVID-19 DAN KEYINGI POSTINFEKSION SINDROMLARNING KLINIK VA IMMUNOLOGIK XUSUSIYATLARI.
Abstract
COVID-19 infeksiyasi bolalarda ko‘pincha yengil yoki simptomsiz kechadi, biroq ayrim hollarda infeksiyadan keyingi davrda og‘ir giperyallig‘lanish holatlari rivojlanadi. Ushbu tadqiqot bolalarda COVID-19 dan keyingi postinfeksion sindromlarning klinik va immunologik xususiyatlarini o‘rganishga bag‘ishlangan. Natijalar shuni ko‘rsatdiki, multisistem yallig‘lanish sindromi (MIS-C) rivojlanishida immun tizim disbalansi va sitokin bo‘roni asosiy rol o‘ynaydi. Klinik belgilar orasida isitma, oshqozon-ichak buzilishlari va yurak-qon tomir tizimi zararlanishi ustunlik qiladi. Laborator ko‘rsatkichlar yallig‘lanish markerlarining oshishini ko‘rsatadi. Erta tashxis va immunomodulyator davolash prognozni yaxshilaydi.
References
1. Feldstein L.R. et al. Multisystem inflammatory syndrome in children. N Engl J Med. 2020.
2. Whittaker E. et al. Clinical characteristics of MIS-C. JAMA. 2020.
3. Consiglio C.R. et al. Immunology of MIS-C. Cell. 2020.
4. Riphagen S. et al. Hyperinflammatory shock in children. Lancet. 2020.
5. Jiang L. et al. COVID-19 and MIS-C. Lancet Infect Dis. 2020.
6. Viner R.M. et al. Kawasaki-like disease. Arch Dis Child. 2020.
7. Carter M.J. et al. Immunophenotypes in MIS-C. Nat Med. 2020.
8. Diorio C. et al. Thrombotic microangiopathy in MIS-C. Blood. 2020.
9. Belhadjer Z. et al. Acute heart failure in MIS-C. Circulation. 2020.
10. World Health Organization. MIS-C guidelines. 2021.
